Assay Detail

CHEMBL4016828

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Functional

Vasorelaxant activity in normal Chinchilla rabbit saphenous artery ring administered at the beginning of the last resting period of 28 mins

ChEMBL ↗

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Target

Saphenous artery (CHEMBL4845615) ↗

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Saphenous artery (CHEMBL4845615) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Saphenous artery

CHEMBL4845615

Anchored from Assay target.

Protein identity Saphenous artery

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Oryctolagus cuniculus
Tissue	Saphenous artery
Confidence	1 — Organism
Curated By	Autocuration

Target

Saphenous artery (CHEMBL4845615) ↗

Type	TISSUE
Organism	Oryctolagus cuniculus

Publication

Discovery of the Soluble Guanylate Cyclase Stimulator Vericiguat (BAY 1021189) for the Treatment of Chronic Heart Failure.

Follmann M, Ackerstaff J, Redlich G, Wunder F, Lang D, Kern A, Fey P, Griebenow N, Kroh W, Becker-Pelster EM, Kretschmer A, Geiss V, Li V, Straub A, Mittendorf J, Jautelat R, Schirok H, Schlemmer KH, Lustig K, Gerisch M, Knorr A, Tinel H, Mondritzki T, Trübel H, Sandner P, Stasch JP.
J Med Chem (2017) 60 : 5146 -5161
PubMed 28557445 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	8.49	8.72

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL730	NITROGLYCERIN	4.0	1	8.72
CHEMBL4066936	VERICIGUAT	4.0	1	8.25

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL730	NITROGLYCERIN	IC50	=	1.9	nM	8.72
CHEMBL4066936	VERICIGUAT	IC50	=	5.6	nM	8.25