Assay Detail
Binding
CHEMBL4016846
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human GST-tagged Clk1 expressed in Escherichia coli using RS repeat substrate peptide after 15 mins in presence of [gamma-32]-ATP
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein kinase CLK1 (CHEMBL4224) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of Selective Clk1 and -4 Inhibitors for Cellular Depletion of Cancer-Relevant Proteins.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.33 | 8.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4082113 | — | — | 1 | 8.16 |
| CHEMBL4085557 | — | — | 1 | 7.35 |
| CHEMBL4070477 | — | — | 1 | 7.09 |
| CHEMBL4103654 | — | — | 1 | 7.08 |
| CHEMBL4064016 | — | — | 1 | 6.97 |
| CHEMBL4077249 | — | — | 1 | - |
| CHEMBL4076404 | — | — | 1 | - |
| CHEMBL4064365 | — | — | 1 | - |
| CHEMBL4088454 | — | — | 1 | - |
| CHEMBL4064031 | — | — | 1 | - |
| CHEMBL4075340 | — | — | 1 | - |
| CHEMBL4093645 | — | — | 1 | - |
| CHEMBL4102695 | — | — | 1 | - |
| CHEMBL4077343 | — | — | 1 | - |
| CHEMBL4094065 | — | — | 1 | - |
| CHEMBL4099320 | — | — | 1 | - |
| CHEMBL4072371 | — | — | 1 | - |
| CHEMBL4067725 | — | — | 1 | - |
| CHEMBL4094143 | — | — | 1 | - |
| CHEMBL4065656 | — | — | 1 | - |
| CHEMBL4075996 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4082113 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL4085557 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4070477 | — | IC50 | = | 81.6 | nM | 7.09 |
| CHEMBL4103654 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4064016 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL4077249 | — | IC50 | - | — | - | |
| CHEMBL4076404 | — | IC50 | - | — | - | |
| CHEMBL4064365 | — | IC50 | - | — | - | |
| CHEMBL4088454 | — | IC50 | - | — | - | |
| CHEMBL4064031 | — | IC50 | - | — | - | |
| CHEMBL4075340 | — | IC50 | - | — | - | |
| CHEMBL4093645 | — | IC50 | - | — | - | |
| CHEMBL4102695 | — | IC50 | - | — | - | |
| CHEMBL4077343 | — | IC50 | - | — | - | |
| CHEMBL4094065 | — | IC50 | - | — | - | |
| CHEMBL4099320 | — | IC50 | - | — | - | |
| CHEMBL4072371 | — | IC50 | - | — | - | |
| CHEMBL4067725 | — | IC50 | - | — | - | |
| CHEMBL4094143 | — | IC50 | - | — | - | |
| CHEMBL4065656 | — | IC50 | - | — | - | |
| CHEMBL4075996 | — | IC50 | - | — | - |