Assay Detail
Functional
CHEMBL4017024
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Cytotoxicity against human A2780cisR cells assessed as cell survival after 72 hrs by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780cisR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.32 | 5.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4080343 | — | — | 1 | 5.79 |
| CHEMBL4069631 | — | — | 1 | 5.79 |
| CHEMBL4090647 | — | — | 1 | 5.73 |
| CHEMBL4098365 | — | — | 1 | 5.66 |
| CHEMBL4059953 | — | — | 1 | 5.50 |
| CHEMBL4074686 | — | — | 1 | 5.48 |
| CHEMBL4095934 | — | — | 1 | 5.42 |
| CHEMBL4095157 | — | — | 1 | 5.38 |
| CHEMBL4082736 | — | — | 1 | 5.37 |
| CHEMBL4088198 | — | — | 1 | 5.29 |
| CHEMBL4100732 | — | — | 1 | 5.29 |
| CHEMBL4066076 | — | — | 1 | 5.09 |
| CHEMBL4068613 | — | — | 1 | 4.37 |
| CHEMBL4090555 | — | — | 1 | 4.30 |
| CHEMBL4060958 | — | — | 1 | - |
| CHEMBL4082838 | — | — | 1 | - |
| CHEMBL4062588 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4080343 | — | IC50 | = | 1610.0 | nM | 5.79 |
| CHEMBL4069631 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL4090647 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL4098365 | — | IC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL4059953 | — | IC50 | = | 3190.0 | nM | 5.50 |
| CHEMBL4074686 | — | IC50 | = | 3310.0 | nM | 5.48 |
| CHEMBL4095934 | — | IC50 | = | 3810.0 | nM | 5.42 |
| CHEMBL4095157 | — | IC50 | = | 4120.0 | nM | 5.38 |
| CHEMBL4082736 | — | IC50 | = | 4290.0 | nM | 5.37 |
| CHEMBL4088198 | — | IC50 | = | 5180.0 | nM | 5.29 |
| CHEMBL4100732 | — | IC50 | = | 5180.0 | nM | 5.29 |
| CHEMBL4066076 | — | IC50 | = | 8210.0 | nM | 5.09 |
| CHEMBL4068613 | — | IC50 | = | 42400.0 | nM | 4.37 |
| CHEMBL4090555 | — | IC50 | = | 50500.0 | nM | 4.30 |
| CHEMBL4060958 | — | IC50 | = | 281000.0 | nM | - |
| CHEMBL4082838 | — | IC50 | = | 107000.0 | nM | - |
| CHEMBL4062588 | — | IC50 | = | 579000.0 | nM | - |