Assay Detail
Binding
CHEMBL4017029
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length human recombinant C-terminal His-tagged HDAC3/NcoR2 expressed in baculovirus infected Sf9 insect cells using Boc-Lys(epsilon-Ac)-AMC as substrate measured after 90 mins by fluorescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) (CHEMBL2111363) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.74 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4069631 | — | — | 1 | 8.19 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.89 |
| CHEMBL4080343 | — | — | 1 | 7.80 |
| CHEMBL4090647 | — | — | 1 | 7.58 |
| CHEMBL4095934 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4069631 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4080343 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4090647 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL4095934 | — | IC50 | = | 60.0 | nM | 7.22 |