Assay Detail
Binding
CHEMBL4017391
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Binding affinity to His-tagged PD-L1 (unknown origin) assessed as reduction in PD-L1/PD1-Ig interaction preincubated with PD-L1 for 15 mins followed by addition of PD1-Ig measured after 15 mins by HTRF assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.95 | 8.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4071326 | — | — | 1 | 8.85 |
| CHEMBL4084368 | — | — | 1 | 8.65 |
| CHEMBL4081869 | — | — | 1 | 8.22 |
| CHEMBL4061613 | — | — | 1 | 8.22 |
| CHEMBL4089730 | — | — | 1 | 7.75 |
| CHEMBL4062686 | — | — | 1 | 7.10 |
| CHEMBL4099869 | — | — | 1 | 6.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4071326 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL4084368 | — | IC50 | = | 2.25 | nM | 8.65 |
| CHEMBL4081869 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4061613 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4089730 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4062686 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL4099869 | — | IC50 | = | 146.0 | nM | 6.84 |