Assay Detail
Binding
CHEMBL4017637
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Inhibition of human topoisomerase 2alpha-mediated kinetoplast DNA decatenation after 60 mins by ethidium bromide staining based agarose gel electrophoresis
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Indenocinnoline derivatives as G-quadruplex binders, topoisomerase IIα inhibitors and antiproliferative agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.99 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.52 |
| CHEMBL4090898 | — | — | 1 | 5.31 |
| CHEMBL4066762 | — | — | 1 | 5.26 |
| CHEMBL4062965 | — | — | 1 | 5.15 |
| CHEMBL4064044 | — | — | 1 | 4.87 |
| CHEMBL4093358 | — | — | 1 | 4.54 |
| CHEMBL4094285 | — | — | 1 | 4.28 |
| CHEMBL4082118 | — | — | 1 | - |
| CHEMBL127717 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4090898 | — | IC50 | = | 4880.0 | nM | 5.31 |
| CHEMBL4066762 | — | IC50 | = | 5440.0 | nM | 5.26 |
| CHEMBL4062965 | — | IC50 | = | 7080.0 | nM | 5.15 |
| CHEMBL4064044 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL4093358 | — | IC50 | = | 29060.0 | nM | 4.54 |
| CHEMBL4094285 | — | IC50 | = | 52890.0 | nM | 4.28 |
| CHEMBL4082118 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL127717 | — | IC50 | > | 100000.0 | nM | - |