Assay Detail
Binding
CHEMBL4017665
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Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and carbonic anhydrase inhibition of a series of SLC-0111 analogs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 6.21 | 6.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4100248 | — | — | 1 | 6.80 |
| CHEMBL1569032 | — | — | 1 | 6.80 |
| CHEMBL4071714 | — | — | 1 | 6.72 |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | 6.60 |
| CHEMBL4090086 | — | — | 1 | 6.56 |
| CHEMBL4092500 | — | — | 1 | 6.51 |
| CHEMBL94551 | — | — | 1 | 6.50 |
| CHEMBL4060262 | — | — | 1 | 6.44 |
| CHEMBL4080618 | — | — | 1 | 6.43 |
| CHEMBL4096209 | — | — | 1 | 6.40 |
| CHEMBL4066371 | — | — | 1 | 6.36 |
| CHEMBL4069119 | — | — | 1 | 6.32 |
| CHEMBL4098655 | — | — | 1 | 6.29 |
| CHEMBL4082231 | — | — | 1 | 6.27 |
| CHEMBL1334282 | — | — | 1 | 6.26 |
| CHEMBL4088487 | — | — | 1 | 6.25 |
| CHEMBL4097801 | — | — | 1 | 6.13 |
| CHEMBL4080725 | — | — | 1 | 5.81 |
| CHEMBL4074460 | — | — | 1 | 5.78 |
| CHEMBL4088593 | — | — | 1 | 5.59 |
| CHEMBL4101198 | — | — | 1 | 5.49 |
| CHEMBL4060361 | — | — | 1 | 5.32 |
| CHEMBL1615281 | SLC-0111 | 1.0 | 1 | 5.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4100248 | — | Ki | = | 158.0 | nM | 6.80 |
| CHEMBL1569032 | — | Ki | = | 158.0 | nM | 6.80 |
| CHEMBL4071714 | — | Ki | = | 192.0 | nM | 6.72 |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL4090086 | — | Ki | = | 275.0 | nM | 6.56 |
| CHEMBL4092500 | — | Ki | = | 307.0 | nM | 6.51 |
| CHEMBL94551 | — | Ki | = | 318.0 | nM | 6.50 |
| CHEMBL4060262 | — | Ki | = | 363.0 | nM | 6.44 |
| CHEMBL4080618 | — | Ki | = | 373.0 | nM | 6.43 |
| CHEMBL4096209 | — | Ki | = | 395.0 | nM | 6.40 |
| CHEMBL4066371 | — | Ki | = | 436.0 | nM | 6.36 |
| CHEMBL4069119 | — | Ki | = | 484.0 | nM | 6.32 |
| CHEMBL4098655 | — | Ki | = | 519.0 | nM | 6.29 |
| CHEMBL4082231 | — | Ki | = | 538.0 | nM | 6.27 |
| CHEMBL1334282 | — | Ki | = | 550.0 | nM | 6.26 |
| CHEMBL4088487 | — | Ki | = | 569.0 | nM | 6.25 |
| CHEMBL4097801 | — | Ki | = | 747.0 | nM | 6.13 |
| CHEMBL4080725 | — | Ki | = | 1560.0 | nM | 5.81 |
| CHEMBL4074460 | — | Ki | = | 1680.0 | nM | 5.78 |
| CHEMBL4088593 | — | Ki | = | 2590.0 | nM | 5.59 |
| CHEMBL4101198 | — | Ki | = | 3260.0 | nM | 5.49 |
| CHEMBL4060361 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL1615281 | SLC-0111 | Ki | = | 5080.0 | nM | 5.29 |