Assay Detail
Binding
CHEMBL4017935
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Inhibition of biotin-labelled L-p53 binding to L-MDM2 (25 to 109 residues) (unknown origin) by FAM labeled P4 peptide based fluorescence polarization assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Investigation of the inhibitory mechanism of apomorphine against MDM2-p53 interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.72 | 6.76 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL416288 | (S)APOMORPHINE | — | 1 | 6.76 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 6.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL416288 | (S)APOMORPHINE | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL53 | APOMORPHINE | IC50 | = | 215.0 | nM | 6.67 |