Assay Detail
Binding
CHEMBL4017936
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Inhibition of biotin-labelled p53 binding to MDM2 (25 to 109 residues) (unknown origin) by surface plasmon resonance method
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Investigation of the inhibitory mechanism of apomorphine against MDM2-p53 interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.86 | 4.86 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8320 | BENZOQUINONE | — | 1 | 4.86 |
| CHEMBL280998 | CATECHOL | — | 1 | - |
| CHEMBL4068121 | — | — | 1 | - |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8320 | BENZOQUINONE | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL280998 | CATECHOL | IC50 | > | 100000.0 | nM | - |
| CHEMBL4068121 | — | Inhibition | - | % | - | |
| CHEMBL53 | APOMORPHINE | Inhibition | - | % | - |