Assay Detail
Binding
CHEMBL4017988
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Inhibition of human BuChE using S-butyrylthiocholine iodide as substrate pretreated for 5 mins followed by substrate addition by Ellman's method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Cytochrome P450 binding studies of novel tacrine derivatives: Predicting the risk of hepatotoxicity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.27 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4076034 | — | — | 1 | 7.70 |
| CHEMBL4070182 | — | — | 1 | 5.85 |
| CHEMBL4075061 | — | — | 1 | 5.80 |
| CHEMBL4091851 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4076034 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4070182 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4075061 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4091851 | — | IC50 | = | 1900.0 | nM | 5.72 |