Assay Detail
Binding
CHEMBL4018050
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Inhibition of recombinant human meprin beta expressed in yeast using Abz-YVAEAPK(Dnp)G-OH as substrate by fluorescence assay
44
Total Activities
44
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
First insight into structure-activity relationships of selective meprin β inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 44 | 5.41 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4078433 | — | — | 1 | 7.22 |
| CHEMBL4105563 | — | — | 1 | 7.22 |
| CHEMBL4099123 | — | — | 1 | 6.66 |
| CHEMBL4102689 | — | — | 1 | 6.57 |
| CHEMBL4083600 | — | — | 1 | 6.51 |
| CHEMBL4087683 | — | — | 1 | 6.50 |
| CHEMBL4072148 | — | — | 1 | 6.47 |
| CHEMBL4096428 | — | — | 1 | 6.40 |
| CHEMBL4101604 | — | — | 1 | 6.39 |
| CHEMBL4063534 | — | — | 1 | 6.37 |
| CHEMBL4067530 | — | — | 1 | 6.19 |
| CHEMBL4083361 | — | — | 1 | 6.16 |
| CHEMBL4079395 | — | — | 1 | 6.01 |
| CHEMBL4071300 | — | — | 1 | 5.97 |
| CHEMBL4098334 | — | — | 1 | 5.97 |
| CHEMBL4061533 | — | — | 1 | 5.71 |
| CHEMBL4097429 | — | — | 1 | 5.59 |
| CHEMBL550148 | — | — | 1 | 5.42 |
| CHEMBL4064607 | — | — | 1 | 5.36 |
| CHEMBL4091383 | — | — | 1 | 5.30 |
| CHEMBL4073192 | — | — | 1 | 5.25 |
| CHEMBL515083 | — | — | 1 | 5.22 |
| CHEMBL4085117 | — | — | 1 | 5.21 |
| CHEMBL4093873 | — | — | 1 | 5.14 |
| CHEMBL4095310 | — | — | 1 | 5.13 |
| CHEMBL83508 | — | — | 1 | 5.04 |
| CHEMBL4084150 | — | — | 1 | 4.99 |
| CHEMBL4087610 | — | — | 1 | 4.84 |
| CHEMBL4079737 | — | — | 1 | 4.83 |
| CHEMBL311932 | — | — | 1 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4078433 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4105563 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4099123 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL4102689 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4083600 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4087683 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4072148 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4096428 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL4101604 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4063534 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4067530 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL4083361 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4079395 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4071300 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4098334 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL4061533 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL4097429 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL550148 | — | IC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL4064607 | — | IC50 | = | 4420.0 | nM | 5.36 |
| CHEMBL4091383 | — | IC50 | = | 5030.0 | nM | 5.30 |
| CHEMBL4073192 | — | IC50 | = | 5650.0 | nM | 5.25 |
| CHEMBL515083 | — | IC50 | = | 5980.0 | nM | 5.22 |
| CHEMBL4085117 | — | IC50 | = | 6190.0 | nM | 5.21 |
| CHEMBL4093873 | — | IC50 | = | 7310.0 | nM | 5.14 |
| CHEMBL4095310 | — | IC50 | = | 7420.0 | nM | 5.13 |
| CHEMBL83508 | — | IC50 | = | 9020.0 | nM | 5.04 |
| CHEMBL4084150 | — | IC50 | = | 10260.0 | nM | 4.99 |
| CHEMBL4087610 | — | IC50 | = | 14320.0 | nM | 4.84 |
| CHEMBL4079737 | — | IC50 | = | 14770.0 | nM | 4.83 |
| CHEMBL311932 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL4066258 | — | IC50 | = | 17170.0 | nM | 4.76 |
| CHEMBL4062444 | — | IC50 | = | 17970.0 | nM | 4.75 |
| CHEMBL198778 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL4070398 | — | IC50 | = | 18850.0 | nM | 4.72 |
| CHEMBL4103999 | — | IC50 | = | 25700.0 | nM | 4.59 |
| CHEMBL4074872 | — | IC50 | = | 26900.0 | nM | 4.57 |
| CHEMBL4060490 | — | IC50 | = | 31200.0 | nM | 4.51 |
| CHEMBL4088725 | — | IC50 | = | 32530.0 | nM | 4.49 |
| CHEMBL82783 | — | IC50 | = | 34950.0 | nM | 4.46 |
| CHEMBL4080850 | — | IC50 | = | 37500.0 | nM | 4.43 |
| CHEMBL86189 | — | IC50 | = | 38800.0 | nM | 4.41 |
| CHEMBL82868 | — | IC50 | = | 40470.0 | nM | 4.39 |
| CHEMBL82331 | — | IC50 | = | 42900.0 | nM | 4.37 |
| CHEMBL4105128 | — | IC50 | = | 43870.0 | nM | 4.36 |