Assay Detail
Binding
CHEMBL4018628
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human FGFR4 using poly (Glu,Tyr) 4:1 as substrate after 60 mins by ELISA
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.22 | 8.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4067871 | — | — | 1 | 8.13 |
| CHEMBL4105329 | — | — | 1 | 7.21 |
| CHEMBL4075917 | — | — | 1 | 7.03 |
| CHEMBL4062877 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4067871 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL4105329 | — | IC50 | = | 61.7 | nM | 7.21 |
| CHEMBL4075917 | — | IC50 | = | 93.3 | nM | 7.03 |
| CHEMBL4062877 | — | IC50 | = | 299.4 | nM | 6.52 |