Assay Detail
Binding
CHEMBL4018869
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant human N-terminal His6-tagged Myt1 kinase domain (75 to 361 residues) by isothermal titration calorimetry
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase (CHEMBL3984) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 6.29 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | 6.82 |
| CHEMBL49120 | PD-0166285 | 1.0 | 1 | 6.61 |
| CHEMBL288441 | BOSUTINIB | 4.0 | 1 | 6.57 |
| CHEMBL1976040 | ADAVOSERTIB | 2.0 | 1 | 6.49 |
| CHEMBL4067978 | — | — | 1 | 6.35 |
| CHEMBL564829 | MILCICLIB | 2.0 | 1 | 6.00 |
| CHEMBL607707 | PELITINIB | 2.0 | 1 | 5.96 |
| CHEMBL217092 | SARACATINIB | 3.0 | 1 | 5.55 |
| CHEMBL4289017 | PF-03814735 | 1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5416410 | DASATINIB | Kd | = | 150.0 | nM | 6.82 |
| CHEMBL49120 | PD-0166285 | Kd | = | 247.0 | nM | 6.61 |
| CHEMBL288441 | BOSUTINIB | Kd | = | 270.0 | nM | 6.57 |
| CHEMBL1976040 | ADAVOSERTIB | Kd | = | 324.0 | nM | 6.49 |
| CHEMBL4067978 | — | Kd | = | 444.0 | nM | 6.35 |
| CHEMBL564829 | MILCICLIB | Kd | = | 990.0 | nM | 6.00 |
| CHEMBL607707 | PELITINIB | Kd | = | 1105.0 | nM | 5.96 |
| CHEMBL217092 | SARACATINIB | Kd | = | 2817.0 | nM | 5.55 |
| CHEMBL4289017 | PF-03814735 | Kd | - | — | - |