Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4019203

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human carbonic anhydrase 2 at +10 charge state for protein to compound complex after 10 mins by nanoESI-MS method
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 2 (CHEMBL205)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Identification of a New Zinc Binding Chemotype by Fragment Screening.
Chrysanthopoulos PK, Mujumdar P, Woods LA, Dolezal O, Ren B, Peat TS, Poulsen SA.
J Med Chem (2017) 60 : 7333 -7349
PubMed 28817930 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 19 4.95 5.57

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4076811 1 5.57
CHEMBL1335 PEMOLINE DIONE 1 5.52
CHEMBL164652 1 5.46
CHEMBL4104501 1 4.80
CHEMBL165079 1 4.74
CHEMBL1958119 1 4.72
CHEMBL305763 1 4.44
CHEMBL4061548 1 4.36
CHEMBL4081175 1 -
CHEMBL1099 DIMETHADIONE 2.0 1 -
CHEMBL695 TRIMETHADIONE 4.0 1 -
CHEMBL4071124 1 -
CHEMBL156406 1 -
CHEMBL2047865 1 -
CHEMBL4066391 1 -
CHEMBL39138 1 -
CHEMBL4077844 1 -
CHEMBL1914996 1 -
CHEMBL39614 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4076811 Kd = 2700.0 nM 5.57
CHEMBL1335 PEMOLINE DIONE Kd = 3000.0 nM 5.52
CHEMBL164652 Kd = 3500.0 nM 5.46
CHEMBL4104501 Kd = 16000.0 nM 4.80
CHEMBL165079 Kd = 18400.0 nM 4.74
CHEMBL1958119 Kd = 19000.0 nM 4.72
CHEMBL305763 Kd = 36200.0 nM 4.44
CHEMBL4061548 Kd = 43600.0 nM 4.36
CHEMBL4081175 Kd - -
CHEMBL1099 DIMETHADIONE Kd - -
CHEMBL695 TRIMETHADIONE Kd - -
CHEMBL4071124 Kd - -
CHEMBL156406 Kd - -
CHEMBL2047865 Kd - -
CHEMBL4066391 Kd - -
CHEMBL39138 Kd - -
CHEMBL4077844 Kd - -
CHEMBL1914996 Kd - -
CHEMBL39614 Kd - -