Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4019565

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human HCT116 cells after 72 hrs by phosphatase assay
ChEMBL ↗
184
Total Activities
184
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Autocuration

Target

HCT-116 (CHEMBL394) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Vinblastine 20' Amides: Synthetic Analogues That Maintain or Improve Potency and Simultaneously Overcome Pgp-Derived Efflux and Resistance.
Lukesh JC, Carney DW, Dong H, Cross RM, Shukla V, Duncan KK, Yang S, Brody DM, Brütsch MM, Radakovic A, Boger DL.
J Med Chem (2017) 60 : 7591 -7604
PubMed 28857558 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 184 8.32 10.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4082738 — — 1 10.15
CHEMBL4090705 — — 1 10.10
CHEMBL4062590 — — 1 10.00
CHEMBL4092592 — — 1 9.74
CHEMBL4094971 — — 1 9.60
CHEMBL4096932 — — 1 9.52
CHEMBL4086760 — — 1 9.52
CHEMBL4081777 — — 1 9.52
CHEMBL4081651 — — 1 9.52
CHEMBL4104663 — — 1 9.48
CHEMBL4068038 — — 1 9.40
CHEMBL4077422 — — 1 9.40
CHEMBL4081021 — — 1 9.40
CHEMBL4059773 — — 1 9.35
CHEMBL4103651 — — 1 9.30
CHEMBL4099650 — — 1 9.30
CHEMBL4069142 — — 1 9.30
CHEMBL4102172 — — 1 9.30
CHEMBL4090557 — — 1 9.22
CHEMBL4096810 — — 1 9.22
CHEMBL4094967 — — 1 9.22
CHEMBL4074214 — — 1 9.22
CHEMBL4098973 — — 1 9.22
CHEMBL4074970 — — 1 9.22
CHEMBL4088850 — — 1 9.22
CHEMBL4068282 — — 1 9.22
CHEMBL4098097 — — 1 9.22
CHEMBL4090047 — — 1 9.22
CHEMBL4060293 — — 1 9.22
CHEMBL4105494 — — 1 9.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4082738 — IC50 = 0.07 nM 10.15
CHEMBL4090705 — IC50 = 0.08 nM 10.10
CHEMBL4062590 — IC50 = 0.1 nM 10.00
CHEMBL4092592 — IC50 = 0.18 nM 9.74
CHEMBL4094971 — IC50 = 0.25 nM 9.60
CHEMBL4081777 — IC50 = 0.3 nM 9.52
CHEMBL4086760 — IC50 = 0.3 nM 9.52
CHEMBL4096932 — IC50 = 0.3 nM 9.52
CHEMBL4081651 — IC50 = 0.3 nM 9.52
CHEMBL4104663 — IC50 = 0.33 nM 9.48
CHEMBL4081021 — IC50 = 0.4 nM 9.40
CHEMBL4068038 — IC50 = 0.4 nM 9.40
CHEMBL4077422 — IC50 = 0.4 nM 9.40
CHEMBL4059773 — IC50 = 0.45 nM 9.35
CHEMBL4102172 — IC50 = 0.5 nM 9.30
CHEMBL4069142 — IC50 = 0.5 nM 9.30
CHEMBL4099650 — IC50 = 0.5 nM 9.30
CHEMBL4103651 — IC50 = 0.5 nM 9.30
CHEMBL4088850 — IC50 = 0.6 nM 9.22
CHEMBL4074970 — IC50 = 0.6 nM 9.22
CHEMBL4068282 — IC50 = 0.6 nM 9.22
CHEMBL4098097 — IC50 = 0.6 nM 9.22
CHEMBL4090047 — IC50 = 0.6 nM 9.22
CHEMBL4060293 — IC50 = 0.6 nM 9.22
CHEMBL4102710 — IC50 = 0.6 nM 9.22
CHEMBL4074214 — IC50 = 0.6 nM 9.22
CHEMBL4094967 — IC50 = 0.6 nM 9.22
CHEMBL4078959 — IC50 = 0.6 nM 9.22
CHEMBL4065379 — IC50 = 0.6 nM 9.22
CHEMBL4094539 — IC50 = 0.6 nM 9.22
CHEMBL4096810 — IC50 = 0.6 nM 9.22
CHEMBL4090557 — IC50 = 0.6 nM 9.22
CHEMBL4105494 — IC50 = 0.6 nM 9.22
CHEMBL4098973 — IC50 = 0.6 nM 9.22
CHEMBL4071460 — IC50 = 0.65 nM 9.19
CHEMBL2179942 — IC50 = 0.7 nM 9.15
CHEMBL4099076 — IC50 = 0.7 nM 9.15
CHEMBL4088822 — IC50 = 0.7 nM 9.15
CHEMBL4092667 — IC50 = 0.7 nM 9.15
CHEMBL4060600 — IC50 = 0.7 nM 9.15
CHEMBL4081996 — IC50 = 0.7 nM 9.15
CHEMBL4096518 — IC50 = 0.7 nM 9.15
CHEMBL4084314 — IC50 = 0.7 nM 9.15
CHEMBL4076093 — IC50 = 0.7 nM 9.15
CHEMBL4099747 — IC50 = 0.7 nM 9.15
CHEMBL4088054 — IC50 = 0.7 nM 9.15
CHEMBL4089456 — IC50 = 0.7 nM 9.15
CHEMBL4069314 — IC50 = 0.7 nM 9.15
CHEMBL4098288 — IC50 = 0.7 nM 9.15
CHEMBL4073901 — IC50 = 0.8 nM 9.10