Assay Detail
Functional
CHEMBL4019744
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity in human HCT116 cells assessed as reduction in cell viability after 72 hrs by MTT assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Small Molecule Inhibitors Simultaneously Targeting Cancer Metabolism and Epigenetics: Discovery of Novel Nicotinamide Phosphoribosyltransferase (NAMPT) and Histone Deacetylase (HDAC) Dual Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.12 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4092869 | — | — | 1 | 6.00 |
| CHEMBL566757 | DAPORINAD | 2.0 | 1 | 5.80 |
| CHEMBL4099640 | — | — | 1 | 5.75 |
| CHEMBL4065412 | — | — | 1 | 5.62 |
| CHEMBL4105561 | — | — | 1 | 5.62 |
| CHEMBL4074493 | — | — | 1 | 5.55 |
| CHEMBL4080695 | — | — | 1 | 5.52 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 5.51 |
| CHEMBL4081642 | — | — | 1 | 5.48 |
| CHEMBL4061360 | — | — | 1 | 5.40 |
| CHEMBL4072816 | — | — | 1 | 5.28 |
| CHEMBL4092104 | — | — | 1 | 5.26 |
| CHEMBL4092530 | — | — | 1 | 5.23 |
| CHEMBL4084779 | — | — | 1 | 5.23 |
| CHEMBL4061419 | — | — | 1 | 5.21 |
| CHEMBL4063132 | — | — | 1 | 5.20 |
| CHEMBL4080754 | — | — | 1 | 5.14 |
| CHEMBL4070033 | — | — | 1 | 5.13 |
| CHEMBL4101228 | — | — | 1 | 5.08 |
| CHEMBL4096345 | — | — | 1 | 5.04 |
| CHEMBL4093482 | — | — | 1 | 5.03 |
| CHEMBL4083264 | — | — | 1 | 5.00 |
| CHEMBL235191 | TACEDINALINE | 3.0 | 1 | 5.00 |
| CHEMBL4089517 | — | — | 1 | 5.00 |
| CHEMBL4069085 | — | — | 1 | 4.96 |
| CHEMBL4099703 | — | — | 1 | 4.85 |
| CHEMBL4070085 | — | — | 1 | 4.82 |
| CHEMBL4071747 | — | — | 1 | 4.82 |
| CHEMBL4097225 | — | — | 1 | 4.75 |
| CHEMBL4081313 | — | — | 1 | 4.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4092869 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL566757 | DAPORINAD | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4099640 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4065412 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4105561 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4074493 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4080695 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4081642 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4061360 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4072816 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL4092104 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4092530 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4084779 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4061419 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4063132 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4080754 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4070033 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL4101228 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4096345 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL4093482 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL4083264 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL235191 | TACEDINALINE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4089517 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4069085 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4099703 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4070085 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4071747 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4097225 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4081313 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL4098798 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL1586371 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL4065864 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL4091055 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL4064385 | — | IC50 | > | 100000.0 | nM | - |