Assay Detail
Binding
CHEMBL4019935
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Competitive binding affinity to human wild type TTR expressed in Escherichia coli BL-21 assessed as equilibrium dissociation constant of second site in presence of ANS by spectrofluorometer
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Stilbene Boronic Acids Form a Covalent Bond with Human Transthyretin and Inhibit Its Aggregation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 12 | 6.21 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2103837 | TAFAMIDIS | 4.0 | 1 | 6.43 |
| CHEMBL4072121 | — | — | 1 | 6.36 |
| CHEMBL4090439 | — | — | 1 | 6.35 |
| CHEMBL4078202 | — | — | 1 | 6.33 |
| CHEMBL4069407 | — | — | 1 | 6.33 |
| CHEMBL165 | RESVERATROL | 3.0 | 1 | 6.33 |
| CHEMBL4063503 | — | — | 1 | 6.33 |
| CHEMBL4099088 | — | — | 1 | 6.14 |
| CHEMBL4065175 | — | — | 1 | 6.10 |
| CHEMBL4102478 | — | — | 1 | 6.09 |
| CHEMBL4082603 | — | — | 1 | 6.00 |
| CHEMBL4060726 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2103837 | TAFAMIDIS | Kd | = | 370.0 | nM | 6.43 |
| CHEMBL4072121 | — | Kd | = | 440.0 | nM | 6.36 |
| CHEMBL4090439 | — | Kd | = | 450.0 | nM | 6.35 |
| CHEMBL4078202 | — | Kd | = | 470.0 | nM | 6.33 |
| CHEMBL4069407 | — | Kd | = | 470.0 | nM | 6.33 |
| CHEMBL165 | RESVERATROL | Kd | = | 470.0 | nM | 6.33 |
| CHEMBL4063503 | — | Kd | = | 470.0 | nM | 6.33 |
| CHEMBL4099088 | — | Kd | = | 730.0 | nM | 6.14 |
| CHEMBL4065175 | — | Kd | = | 790.0 | nM | 6.10 |
| CHEMBL4102478 | — | Kd | = | 820.0 | nM | 6.09 |
| CHEMBL4082603 | — | Kd | = | 990.0 | nM | 6.00 |
| CHEMBL4060726 | — | Kd | = | 1800.0 | nM | 5.75 |