Compound Detail
CHEMBL4102478
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Basic Information
| ChEMBL ID | CHEMBL4102478 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KRMYCYOJAKTMEN-OWOJBTEDSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
281.1
MW (Da)
4.58
ALogP
2
HBA
2
HBD
40.5
PSA (Ų)
0.79
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 6.09
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Transthyretin CHEMBL3194 | Kd | 6.09 | 6.09 | 820.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Transthyretin | Kd | = | 820.0 | nM | 6.09 | Competitive binding affinity to human wild type TTR expressed in Escherichia col... | 28920684 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 28920684 | 10.1021/acs.jmedchem.7b00952 | Transthyretin | 5 |
Data from ChEMBL 36 via Core Engine