Assay Detail
Binding
CHEMBL4019946
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Inhibition of MDM2 in human U87MG cells assessed as reduction in MDM2 interaction with p53 after 10 mins by quantitative sandwich immune-enzymatic assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 7.46 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4095983 | — | — | 1 | 8.11 |
| CHEMBL4064911 | — | — | 1 | 8.04 |
| CHEMBL4102803 | — | — | 1 | 8.02 |
| CHEMBL4100348 | — | — | 1 | 7.86 |
| CHEMBL4080951 | — | — | 1 | 7.72 |
| CHEMBL4084848 | — | — | 1 | 7.63 |
| CHEMBL4105199 | — | — | 1 | 7.45 |
| CHEMBL4074577 | — | — | 1 | 7.37 |
| CHEMBL4073512 | — | — | 1 | 7.30 |
| CHEMBL4095042 | — | — | 1 | 7.18 |
| CHEMBL4065471 | — | — | 1 | 7.03 |
| CHEMBL2152332 | — | — | 1 | 6.97 |
| CHEMBL4092607 | — | — | 1 | 6.94 |
| CHEMBL4068667 | — | — | 1 | 6.85 |
| CHEMBL3347643 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4095983 | — | IC50 | = | 7.85 | nM | 8.11 |
| CHEMBL4064911 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL4102803 | — | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL4100348 | — | IC50 | = | 13.8 | nM | 7.86 |
| CHEMBL4080951 | — | IC50 | = | 18.9 | nM | 7.72 |
| CHEMBL4084848 | — | IC50 | = | 23.4 | nM | 7.63 |
| CHEMBL4105199 | — | IC50 | = | 35.4 | nM | 7.45 |
| CHEMBL4074577 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4073512 | — | IC50 | = | 50.3 | nM | 7.30 |
| CHEMBL4095042 | — | IC50 | = | 65.3 | nM | 7.18 |
| CHEMBL4065471 | — | IC50 | = | 93.7 | nM | 7.03 |
| CHEMBL2152332 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL4092607 | — | IC50 | = | 115.0 | nM | 6.94 |
| CHEMBL4068667 | — | IC50 | = | 141.5 | nM | 6.85 |
| CHEMBL3347643 | — | IC50 | > | 1000.0 | nM | - |