Assay Detail
Binding
CHEMBL4020032
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of rabbit muscle glycogen phosphorylase b using glucose-1-phosphate as substrate in presence of constant concentrations of glycogen and AMP
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glycogen phosphorylase, muscle form (CHEMBL4696) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Nanomolar Inhibitors of Glycogen Phosphorylase Based on β-d-Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 4.82 | 5.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4081944 | — | — | 1 | 5.26 |
| CHEMBL558445 | — | — | 1 | 5.05 |
| CHEMBL600003 | — | — | 1 | 4.80 |
| CHEMBL4090219 | — | — | 1 | 4.57 |
| CHEMBL560324 | — | — | 1 | 4.42 |
| CHEMBL601227 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4081944 | — | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL558445 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL600003 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL4090219 | — | Ki | = | 27100.0 | nM | 4.57 |
| CHEMBL560324 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL601227 | — | Ki | = | 151000.0 | nM | - |