Assay Detail
Binding
CHEMBL4020036
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of rabbit muscle glycogen phosphorylase-b in presence of varying levels of glucose-1-phosphate and constant concentration of glycogen and AMP preincubated for 15 mins with AMP and glycogen followed by glucose-1-phosphate addition by Lineweaver-Burk plot method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Glycogen phosphorylase, muscle form (CHEMBL4696) ↗| Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
Publication
Nanomolar Inhibitors of Glycogen Phosphorylase Based on β-d-Glucosaminyl Heterocycles: A Combined Synthetic, Enzyme Kinetic, and Protein Crystallography Study.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.52 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4101331 | — | — | 1 | 6.72 |
| CHEMBL4095486 | — | — | 1 | 5.57 |
| CHEMBL4068103 | — | — | 1 | 5.32 |
| CHEMBL4087784 | — | — | 1 | 4.45 |
| CHEMBL4105675 | — | — | 1 | - |
| CHEMBL4098082 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4101331 | — | Ki | = | 191.0 | nM | 6.72 |
| CHEMBL4095486 | — | Ki | = | 2670.0 | nM | 5.57 |
| CHEMBL4068103 | — | Ki | = | 4800.0 | nM | 5.32 |
| CHEMBL4087784 | — | Ki | = | 35200.0 | nM | 4.45 |
| CHEMBL4105675 | — | Ki | = | 354300.0 | nM | - |
| CHEMBL4098082 | — | Ki | = | 107100.0 | nM | - |