Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4020039

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to GST tagged EED (unknown origin) after 1 hr by OG(488) probe based TR-FRET assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Polycomb protein EED (CHEMBL2189117)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Are We There Yet? Applying Thermodynamic and Kinetic Profiling on Embryonic Ectoderm Development (EED) Hit-to-Lead Program.
Wang Y, Edalji RP, Panchal SC, Sun C, Djuric SW, Vasudevan A.
J Med Chem (2017) 60 : 8321 -8335
PubMed 28926243 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 24 7.68 9.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4084398 1 9.52
CHEMBL4104741 1 9.52
CHEMBL4060827 1 9.15
CHEMBL4080018 1 9.00
CHEMBL4102320 1 8.52
CHEMBL4081496 1 8.52
CHEMBL4071358 1 8.52
CHEMBL4085428 1 8.40
CHEMBL4100850 1 8.10
CHEMBL4072980 1 8.00
CHEMBL4075197 1 8.00
CHEMBL4078052 1 7.92
CHEMBL4077899 1 7.75
CHEMBL4079004 1 7.75
CHEMBL4092154 1 7.38
CHEMBL4067115 1 7.10
CHEMBL4103307 1 7.04
CHEMBL4085375 1 6.96
CHEMBL4093678 1 6.54
CHEMBL4093134 1 6.35
CHEMBL4074159 1 6.22
CHEMBL4064198 1 6.17
CHEMBL51594 1 6.02
CHEMBL4074086 1 5.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4084398 Ki = 0.3 nM 9.52
CHEMBL4104741 Ki = 0.3 nM 9.52
CHEMBL4060827 Ki = 0.7 nM 9.15
CHEMBL4080018 Ki = 1.0 nM 9.00
CHEMBL4102320 Ki = 3.0 nM 8.52
CHEMBL4081496 Ki = 3.0 nM 8.52
CHEMBL4071358 Ki = 3.0 nM 8.52
CHEMBL4085428 Ki = 4.0 nM 8.40
CHEMBL4100850 Ki = 8.0 nM 8.10
CHEMBL4072980 Ki = 10.0 nM 8.00
CHEMBL4075197 Ki = 10.0 nM 8.00
CHEMBL4078052 Ki = 12.0 nM 7.92
CHEMBL4077899 Ki = 18.0 nM 7.75
CHEMBL4079004 Ki = 18.0 nM 7.75
CHEMBL4092154 Ki = 42.0 nM 7.38
CHEMBL4067115 Ki = 80.0 nM 7.10
CHEMBL4103307 Ki = 91.0 nM 7.04
CHEMBL4085375 Ki = 110.0 nM 6.96
CHEMBL4093678 Ki = 290.0 nM 6.54
CHEMBL4093134 Ki = 450.0 nM 6.35
CHEMBL4074159 Ki = 600.0 nM 6.22
CHEMBL4064198 Ki = 680.0 nM 6.17
CHEMBL51594 Ki = 950.0 nM 6.02
CHEMBL4074086 Ki = 1500.0 nM 5.82