Assay Detail
Binding
CHEMBL4020190
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Inhibition of human N-terminal His-tagged BTK expressed in bacmid transfected Sf21 insect cells using TK-substrate-biotin after 40 mins by HTRF assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.50 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4101977 | — | — | 1 | 8.10 |
| CHEMBL4091764 | — | — | 1 | 6.82 |
| CHEMBL4073371 | — | — | 1 | 6.57 |
| CHEMBL4064000 | — | — | 1 | 6.48 |
| CHEMBL4100228 | — | — | 1 | 6.28 |
| CHEMBL1354522 | — | — | 1 | 5.96 |
| CHEMBL4079354 | — | — | 1 | 5.92 |
| CHEMBL4103618 | — | — | 1 | 5.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4101977 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4091764 | — | IC50 | = | 153.0 | nM | 6.82 |
| CHEMBL4073371 | — | IC50 | = | 271.0 | nM | 6.57 |
| CHEMBL4064000 | — | IC50 | = | 334.0 | nM | 6.48 |
| CHEMBL4100228 | — | IC50 | = | 526.0 | nM | 6.28 |
| CHEMBL1354522 | — | IC50 | = | 1091.0 | nM | 5.96 |
| CHEMBL4079354 | — | IC50 | = | 1213.0 | nM | 5.92 |
| CHEMBL4103618 | — | IC50 | = | 1380.0 | nM | 5.86 |