Assay Detail
Functional
CHEMBL4020218
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MX1 cells after 72 hrs by Cell Titer Glo assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MX1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 32 | 7.20 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3933555 | — | — | 1 | 8.10 |
| CHEMBL3987016 | MIVEBRESIB | 2.0 | 1 | 7.89 |
| CHEMBL3898684 | — | — | 1 | 7.85 |
| CHEMBL3948433 | — | — | 1 | 7.85 |
| CHEMBL3970220 | — | — | 1 | 7.80 |
| CHEMBL3933860 | — | — | 1 | 7.77 |
| CHEMBL3911104 | — | — | 1 | 7.72 |
| CHEMBL4098055 | — | — | 1 | 7.66 |
| CHEMBL3901761 | — | — | 1 | 7.57 |
| CHEMBL3974260 | — | — | 1 | 7.54 |
| CHEMBL4059602 | — | — | 1 | 7.52 |
| CHEMBL3904317 | — | — | 1 | 7.51 |
| CHEMBL3942897 | — | — | 1 | 7.47 |
| CHEMBL3889757 | — | — | 1 | 7.34 |
| CHEMBL3928793 | — | — | 1 | 7.34 |
| CHEMBL3973984 | — | — | 1 | 7.28 |
| CHEMBL3980661 | — | — | 1 | 7.25 |
| CHEMBL3898479 | — | — | 1 | 7.19 |
| CHEMBL3926000 | — | — | 1 | 7.14 |
| CHEMBL3963357 | — | — | 1 | 7.11 |
| CHEMBL4060619 | — | — | 1 | 7.08 |
| CHEMBL4061028 | — | — | 1 | 7.07 |
| CHEMBL3964603 | — | — | 1 | 6.96 |
| CHEMBL3914893 | — | — | 1 | 6.92 |
| CHEMBL3967185 | — | — | 1 | 6.89 |
| CHEMBL3919590 | — | — | 1 | 6.89 |
| CHEMBL4089203 | — | — | 1 | 6.68 |
| CHEMBL1957266 | — | — | 1 | 6.59 |
| CHEMBL3980983 | — | — | 1 | 6.26 |
| CHEMBL4082851 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3933555 | — | EC50 | = | 7.9 | nM | 8.10 |
| CHEMBL3987016 | MIVEBRESIB | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3898684 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3948433 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3970220 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3933860 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3911104 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4098055 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL3901761 | — | EC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3974260 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4059602 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3904317 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3942897 | — | EC50 | = | 34.0 | nM | 7.47 |
| CHEMBL3889757 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3928793 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3973984 | — | EC50 | = | 52.0 | nM | 7.28 |
| CHEMBL3980661 | — | EC50 | = | 56.0 | nM | 7.25 |
| CHEMBL3898479 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL3926000 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL3963357 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4060619 | — | EC50 | = | 83.0 | nM | 7.08 |
| CHEMBL4061028 | — | EC50 | = | 86.0 | nM | 7.07 |
| CHEMBL3964603 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL3914893 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL3967185 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3919590 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4089203 | — | EC50 | = | 210.0 | nM | 6.68 |
| CHEMBL1957266 | — | EC50 | = | 254.0 | nM | 6.59 |
| CHEMBL3980983 | — | EC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4082851 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4088769 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4100828 | — | EC50 | > | 5000.0 | nM | - |