Assay Detail
Binding
CHEMBL4020948
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [20-3H]phorbol 12,13-dibutyrate from PKCalpha (unknown origin) in the presence of porcine brain phosphatidylserine by scintillation counting
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploring the influence of indololactone structure on selectivity for binding to the C1 domains of PKCα, PKCε, and RasGRP.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.88 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL519741 | — | — | 1 | 7.89 |
| CHEMBL4075373 | — | — | 1 | 7.14 |
| CHEMBL4070999 | — | — | 1 | 7.08 |
| CHEMBL4099579 | — | — | 1 | 6.97 |
| CHEMBL4097154 | — | — | 1 | 6.94 |
| CHEMBL4069954 | — | — | 1 | 6.59 |
| CHEMBL4081576 | — | — | 1 | 6.30 |
| CHEMBL4066764 | — | — | 1 | 6.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL519741 | — | Ki | = | 12.9 | nM | 7.89 |
| CHEMBL4075373 | — | Ki | = | 73.0 | nM | 7.14 |
| CHEMBL4070999 | — | Ki | = | 83.1 | nM | 7.08 |
| CHEMBL4099579 | — | Ki | = | 106.0 | nM | 6.97 |
| CHEMBL4097154 | — | Ki | = | 116.0 | nM | 6.94 |
| CHEMBL4069954 | — | Ki | = | 257.0 | nM | 6.59 |
| CHEMBL4081576 | — | Ki | = | 504.0 | nM | 6.30 |
| CHEMBL4066764 | — | Ki | = | 698.0 | nM | 6.16 |