Assay Detail
Functional
CHEMBL4021200
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Growth inhibition of human NCI-H1993 cells after 72 hrs by CCK-8 assay
28
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H1993 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Identification of 3-substituted-6-(1-(1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)quinoline derivatives as highly potent and selective mesenchymal-epithelial transition factor (c-Met) inhibitors via metabolite profiling-based structural optimization.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 8.92 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4064183 | — | — | 1 | 9.70 |
| CHEMBL4076438 | — | — | 1 | 9.70 |
| CHEMBL4104884 | — | — | 1 | 9.40 |
| CHEMBL4091023 | — | — | 1 | 9.30 |
| CHEMBL4074262 | — | — | 3 | 9.22 |
| CHEMBL4070258 | — | — | 1 | 9.10 |
| CHEMBL4097173 | — | — | 1 | 9.10 |
| CHEMBL4060354 | — | — | 1 | 9.05 |
| CHEMBL4070051 | — | — | 1 | 9.05 |
| CHEMBL4061378 | — | — | 1 | 9.05 |
| CHEMBL4083235 | — | — | 1 | 9.05 |
| CHEMBL4092293 | — | — | 1 | 8.96 |
| CHEMBL4093803 | — | — | 1 | 8.92 |
| CHEMBL3188267 | CAPMATINIB | 4.0 | 1 | 8.64 |
| CHEMBL4102466 | — | — | 1 | 8.59 |
| CHEMBL4068290 | — | — | 1 | 8.49 |
| CHEMBL4065641 | — | — | 1 | 8.46 |
| CHEMBL4078192 | — | — | 1 | 8.44 |
| CHEMBL4094716 | — | — | 1 | 8.39 |
| CHEMBL4099662 | — | — | 1 | 8.38 |
| CHEMBL4072776 | — | — | 1 | 8.06 |
| CHEMBL4073110 | — | — | 1 | - |
| CHEMBL4075149 | — | — | 1 | - |
| CHEMBL4081567 | — | — | 1 | - |
| CHEMBL4059611 | — | — | 1 | - |
| CHEMBL4089433 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4064183 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4076438 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL4104884 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL4091023 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL4074262 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4074262 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL4070258 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4097173 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4083235 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4060354 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4061378 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4070051 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL4074262 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4092293 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4093803 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL3188267 | CAPMATINIB | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL4102466 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL4068290 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL4065641 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL4078192 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL4094716 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL4099662 | — | IC50 | = | 4.2 | nM | 8.38 |
| CHEMBL4072776 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL4073110 | — | IC50 | - | — | - | |
| CHEMBL4081567 | — | IC50 | - | — | - | |
| CHEMBL4059611 | — | IC50 | - | — | - | |
| CHEMBL4075149 | — | IC50 | - | — | - | |
| CHEMBL4089433 | — | IC50 | - | — | - |