Assay Detail
Binding
CHEMBL4021259
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDGFRalpha (unknown origin) by HTRF method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Platelet-derived growth factor receptor alpha (CHEMBL2007) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and evaluation of a series of pyridine and pyrimidine derivatives as type II c-Met inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.89 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 9.37 |
| CHEMBL460702 | BMS-777607 | 2.0 | 1 | 7.55 |
| CHEMBL4104302 | — | — | 1 | 6.76 |
| CHEMBL2105717 | CABOZANTINIB | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL460702 | BMS-777607 | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4104302 | — | IC50 | = | 172.0 | nM | 6.76 |
| CHEMBL2105717 | CABOZANTINIB | IC50 | > | 10000.0 | nM | - |