Assay Detail
Binding
CHEMBL4021429
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ob/ob mouse plasma DPP4
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Approaches towards the development of chimeric DPP4/ACE inhibitors for treating metabolic syndrome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.21 | 7.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1422 | SITAGLIPTIN | 4.0 | 1 | 7.34 |
| CHEMBL4067185 | — | — | 1 | 6.66 |
| CHEMBL4086264 | — | — | 1 | 6.31 |
| CHEMBL4078112 | — | — | 1 | 5.61 |
| CHEMBL4090635 | — | — | 1 | 5.14 |
| CHEMBL577 | ENALAPRILAT ANHYDROUS | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1422 | SITAGLIPTIN | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4067185 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL4086264 | — | IC50 | = | 488.0 | nM | 6.31 |
| CHEMBL4078112 | — | IC50 | = | 2470.0 | nM | 5.61 |
| CHEMBL4090635 | — | IC50 | = | 7170.0 | nM | 5.14 |
| CHEMBL577 | ENALAPRILAT ANHYDROUS | IC50 | - | — | - |