Assay Detail
Binding
CHEMBL4021433
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human plasma ACE
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Approaches towards the development of chimeric DPP4/ACE inhibitors for treating metabolic syndrome.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.05 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL577 | ENALAPRILAT ANHYDROUS | 4.0 | 1 | 8.60 |
| CHEMBL4086264 | — | — | 1 | 8.07 |
| CHEMBL4078112 | — | — | 1 | 7.29 |
| CHEMBL4067185 | — | — | 1 | 6.80 |
| CHEMBL4090635 | — | — | 1 | 6.55 |
| CHEMBL1422 | SITAGLIPTIN | 4.0 | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL577 | ENALAPRILAT ANHYDROUS | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4086264 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL4078112 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4067185 | — | IC50 | = | 158.0 | nM | 6.80 |
| CHEMBL4090635 | — | IC50 | = | 279.0 | nM | 6.55 |
| CHEMBL1422 | SITAGLIPTIN | IC50 | = | 11000.0 | nM | 4.96 |