Assay Detail
Binding
CHEMBL4021779
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-R1881 from AR in human LNCaP cells preincubated for 30 mins followed by [3H]-R1881 addition measured after 30 mins by microbeta scintillation counter method
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of deuterated apalutamide with improved pharmacokinetic profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.80 | 7.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4105484 | — | — | 1 | 7.81 |
| CHEMBL3183409 | APALUTAMIDE | 4.0 | 1 | 7.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4105484 | — | IC50 | = | 15.41 | nM | 7.81 |
| CHEMBL3183409 | APALUTAMIDE | IC50 | = | 16.25 | nM | 7.79 |