Assay Detail
Functional
CHEMBL4022302
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Antiproliferative activity against human HCT116 cells after 48 to 72 hrs by MTT assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of 4-piperazinyl-containing Chidamide derivatives as HDACs inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.42 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4071757 | — | — | 1 | 7.16 |
| CHEMBL4087968 | — | — | 1 | 6.70 |
| CHEMBL4088425 | — | — | 1 | 6.12 |
| CHEMBL4096149 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4071757 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4087968 | — | IC50 | = | 202.0 | nM | 6.70 |
| CHEMBL4088425 | — | IC50 | = | 765.0 | nM | 6.12 |
| CHEMBL4096149 | — | IC50 | = | 1977.0 | nM | 5.70 |