Assay Detail
Binding
CHEMBL4022632
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-Xa-tagged human AAK1 expressed in bacterial system using fluoresceinated peptide (5 -FAM)-Aha-KEEQSQITSQVTGQIGWR-NH2 and ATP incubated for 3 hrs
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibitors of Adaptor-Associated Kinase 1 (AAK1) May Treat Neuropathic Pain, Schizophrenia, Parkinson's Disease, and Other Disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.55 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4085072 | — | — | 1 | 10.15 |
| CHEMBL4065155 | — | — | 1 | 9.64 |
| CHEMBL4084103 | — | — | 1 | 9.49 |
| CHEMBL4062388 | — | — | 1 | 9.38 |
| CHEMBL4092824 | — | — | 1 | 9.29 |
| CHEMBL4073745 | — | — | 1 | 8.52 |
| CHEMBL4066208 | — | — | 1 | 6.05 |
| CHEMBL4103020 | — | — | 1 | 5.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4085072 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL4065155 | — | IC50 | = | 0.23 | nM | 9.64 |
| CHEMBL4084103 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL4062388 | — | IC50 | = | 0.42 | nM | 9.38 |
| CHEMBL4092824 | — | IC50 | = | 0.51 | nM | 9.29 |
| CHEMBL4073745 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4066208 | — | IC50 | = | 886.0 | nM | 6.05 |
| CHEMBL4103020 | — | IC50 | = | 1400.0 | nM | 5.85 |