Assay Detail
Binding
CHEMBL4022686
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human GSK3alpha using biotin-CREB peptide substrate after 1 hr by scintillation counting method
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.94 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3185148 | — | — | 1 | 8.15 |
| CHEMBL412142 | LADUVIGLUSIB | 1.0 | 1 | 8.11 |
| CHEMBL1080901 | — | — | 1 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3185148 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL412142 | LADUVIGLUSIB | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL1080901 | — | IC50 | = | 27.1 | nM | 7.57 |