Assay Detail
Functional
CHEMBL4023896
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antileishmanial activity against Leishmania infantum isolate LEM3323 after 3 to 5 days
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Leishmania infantum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of (6 R)-2-Nitro-6-[4-(trifluoromethoxy)phenoxy]-6,7-dihydro-5 H-imidazo[2,1- b][1,3]oxazine (DNDI-8219): A New Lead for Visceral Leishmaniasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.89 | 6.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL125 | MILTEFOSINE | 4.0 | 1 | 6.13 |
| CHEMBL4078293 | — | — | 1 | 5.65 |
| CHEMBL4075089 | — | — | 1 | - |
| CHEMBL267345 | AMPHOTERICIN B | 4.0 | 1 | - |
| CHEMBL370143 | PAROMOMYCIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL125 | MILTEFOSINE | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4078293 | — | IC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL4075089 | — | IC50 | - | — | - | |
| CHEMBL267345 | AMPHOTERICIN B | IC50 | - | — | - | |
| CHEMBL370143 | PAROMOMYCIN | IC50 | = | 142000.0 | nM | - |