Assay Detail
Binding
CHEMBL4023909
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of human HA-tagged APJ receptor internalization expressed in HEK293 cells after 30 mins by ELISA
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A Systematic Exploration of Macrocyclization in Apelin-13: Impact on Binding, Signaling, Stability, and Cardiovascular Effects.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 7.10 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3184840 | — | — | 1 | 7.62 |
| CHEMBL4094033 | — | — | 1 | 7.35 |
| CHEMBL4076755 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3184840 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4094033 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4076755 | — | EC50 | = | 469.0 | nM | 6.33 |