Assay Detail
Binding
CHEMBL4023935
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Binding affinity to CA1 (unknown origin) assessed as intrinsic thermodynamic equilibrium constant at pH 7 by SPR assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Introduction of Intrinsic Kinetics of Protein-Ligand Interactions and Their Implications for Drug Design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 11 | 8.56 | 10.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2010994 | — | — | 1 | 10.42 |
| CHEMBL2011156 | — | — | 1 | 9.27 |
| CHEMBL3797385 | — | — | 1 | 9.15 |
| CHEMBL2443188 | — | — | 1 | 9.12 |
| CHEMBL3798446 | — | — | 1 | 8.85 |
| CHEMBL3799945 | — | — | 1 | 8.62 |
| CHEMBL3799577 | — | — | 1 | 8.37 |
| CHEMBL2443189 | — | — | 1 | 8.17 |
| CHEMBL2011155 | — | — | 1 | 6.96 |
| CHEMBL3799296 | — | — | 1 | 6.70 |
| CHEMBL2333416 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2010994 | — | Kd | = | 0.038 | nM | 10.42 |
| CHEMBL2011156 | — | Kd | = | 0.54 | nM | 9.27 |
| CHEMBL3797385 | — | Kd | = | 0.7 | nM | 9.15 |
| CHEMBL2443188 | — | Kd | = | 0.76 | nM | 9.12 |
| CHEMBL3798446 | — | Kd | = | 1.4 | nM | 8.85 |
| CHEMBL3799945 | — | Kd | = | 2.4 | nM | 8.62 |
| CHEMBL3799577 | — | Kd | = | 4.3 | nM | 8.37 |
| CHEMBL2443189 | — | Kd | = | 6.8 | nM | 8.17 |
| CHEMBL2011155 | — | Kd | = | 110.0 | nM | 6.96 |
| CHEMBL3799296 | — | Kd | = | 200.0 | nM | 6.70 |
| CHEMBL2333416 | — | Kd | = | 0.0032 | nM | - |