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Assay Detail

CHEMBL4023938

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Binding
Binding affinity to CA7 (unknown origin) assessed as intrinsic thermodynamic equilibrium constant at pH 7 by SPR assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 7 (CHEMBL2326)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Introduction of Intrinsic Kinetics of Protein-Ligand Interactions and Their Implications for Drug Design.
Linkuvienė V, Talibov VO, Danielson UH, Matulis D.
J Med Chem (2018) 61 : 2292 -2302
PubMed 29466001 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 17 9.08 10.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2011156 1 10.68
CHEMBL3797385 1 10.42
CHEMBL2443188 1 10.00
CHEMBL3799577 1 9.77
CHEMBL2333416 1 9.72
CHEMBL2010994 1 9.64
CHEMBL3798446 1 9.48
CHEMBL3797893 1 9.18
CHEMBL3359181 1 8.77
CHEMBL3799296 1 8.68
CHEMBL1272242 1 8.62
CHEMBL2011155 1 8.44
CHEMBL2443189 1 8.41
CHEMBL3359179 1 8.31
CHEMBL1272187 1 7.89
CHEMBL3799945 1 7.23
CHEMBL3798473 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2011156 Kd = 0.021 nM 10.68
CHEMBL3797385 Kd = 0.038 nM 10.42
CHEMBL2443188 Kd = 0.1 nM 10.00
CHEMBL3799577 Kd = 0.17 nM 9.77
CHEMBL2333416 Kd = 0.19 nM 9.72
CHEMBL2010994 Kd = 0.23 nM 9.64
CHEMBL3798446 Kd = 0.33 nM 9.48
CHEMBL3797893 Kd = 0.66 nM 9.18
CHEMBL3359181 Kd = 1.7 nM 8.77
CHEMBL3799296 Kd = 2.1 nM 8.68
CHEMBL1272242 Kd = 2.4 nM 8.62
CHEMBL2011155 Kd = 3.6 nM 8.44
CHEMBL2443189 Kd = 3.9 nM 8.41
CHEMBL3359179 Kd = 4.9 nM 8.31
CHEMBL1272187 Kd = 13.0 nM 7.89
CHEMBL3799945 Kd = 59.0 nM 7.23
CHEMBL3798473 Kd = 0.0041 nM -