Assay Detail
Functional
CHEMBL4024005
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Induction of necroptosis in mouse L929 cells assessed as increase in TNFalpha/zVAD-FMK-induced LDH release preincubated for 30 mins followed by TNFalpha/zVAD-FMK addition measured after 4 hrs by CytoTox 96 nonradioactive cytotoxicity assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | L929 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 7.82 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4100398 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4100398 | — | IC50 | = | 15.0 | nM | 7.82 |