Assay Detail
Binding
CHEMBL4024807
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of IRAP (unknown origin) expressed in HEK 293S GnTI(-) cells by in vitro fluorimetric assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Optimization and Structure-Activity Relationships of Phosphinic Pseudotripeptide Inhibitors of Aminopeptidases That Generate Antigenic Peptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 7.18 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4101200 | — | — | 1 | 8.70 |
| CHEMBL4095882 | — | — | 1 | 8.40 |
| CHEMBL4077855 | — | — | 1 | 8.05 |
| CHEMBL4099107 | — | — | 1 | 8.00 |
| CHEMBL4081073 | — | — | 1 | 7.89 |
| CHEMBL4080145 | — | — | 1 | 7.89 |
| CHEMBL4089555 | — | — | 1 | 7.85 |
| CHEMBL4069576 | — | — | 1 | 7.80 |
| CHEMBL4069425 | — | — | 1 | 7.75 |
| CHEMBL4104383 | — | — | 1 | 7.70 |
| CHEMBL4094131 | — | — | 1 | 7.68 |
| CHEMBL4097268 | — | — | 1 | 7.54 |
| CHEMBL4081682 | — | — | 1 | 7.50 |
| CHEMBL4065841 | — | — | 1 | 7.50 |
| CHEMBL4103640 | — | — | 1 | 7.47 |
| CHEMBL4099693 | — | — | 1 | 7.39 |
| CHEMBL4085707 | — | — | 1 | 7.39 |
| CHEMBL4074464 | — | — | 1 | 7.34 |
| CHEMBL3416733 | — | — | 1 | 7.24 |
| CHEMBL4091951 | — | — | 1 | 6.99 |
| CHEMBL4077711 | — | — | 1 | 6.73 |
| CHEMBL4096799 | — | — | 1 | 6.66 |
| CHEMBL4073490 | — | — | 1 | 6.55 |
| CHEMBL4086352 | — | — | 1 | 6.50 |
| CHEMBL4066723 | — | — | 1 | 6.42 |
| CHEMBL4096656 | — | — | 1 | 6.36 |
| CHEMBL4093454 | — | — | 1 | 6.25 |
| CHEMBL4064891 | — | — | 1 | 6.24 |
| CHEMBL4070078 | — | — | 1 | 5.76 |
| CHEMBL4088020 | — | — | 1 | 5.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4101200 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4095882 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4077855 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4099107 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4081073 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4080145 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4089555 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4069576 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4069425 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4104383 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4094131 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4097268 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4081682 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4065841 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4103640 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4099693 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4085707 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4074464 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL3416733 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4091951 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL4077711 | — | IC50 | = | 185.0 | nM | 6.73 |
| CHEMBL4096799 | — | IC50 | = | 221.0 | nM | 6.66 |
| CHEMBL4073490 | — | IC50 | = | 281.0 | nM | 6.55 |
| CHEMBL4086352 | — | IC50 | = | 317.0 | nM | 6.50 |
| CHEMBL4066723 | — | IC50 | = | 381.0 | nM | 6.42 |
| CHEMBL4096656 | — | IC50 | = | 434.0 | nM | 6.36 |
| CHEMBL4093454 | — | IC50 | = | 561.0 | nM | 6.25 |
| CHEMBL4064891 | — | IC50 | = | 577.0 | nM | 6.24 |
| CHEMBL4070078 | — | IC50 | = | 1754.0 | nM | 5.76 |
| CHEMBL4088020 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4095735 | — | IC50 | = | 4024.0 | nM | 5.39 |