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Assay Detail

CHEMBL4026076

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Functional
Antitubercular activity against Mycobacterium bovis BCG ATCC 35743 dormant stage by nitrate reductase based two-fold dilution assay
ChEMBL ↗
46
Total Activities
23
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Mycobacterium tuberculosis
Confidence 1 — Organism
Curated By Autocuration

Target

Mycobacterium tuberculosis (CHEMBL360) ↗
Type ORGANISM
Organism Mycobacterium tuberculosis

Publication

Synthesis and antimycobacterial screening of new thiazolyl-oxazole derivatives.
Abhale YK, Sasane AV, Chavan AP, Shekh SH, Deshmukh KK, Bhansali S, Nawale L, Sarkar D, Mhaske PC.
Eur J Med Chem (2017) 132 : 333 -340
PubMed 28411559 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 23 6.37 7.40
MIC90 23 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL374478 RIFAMPIN 4.0 2 7.40
CHEMBL4095832 — — 2 6.72
CHEMBL4084902 — — 2 6.50
CHEMBL4103590 — — 2 6.44
CHEMBL4065075 — — 2 6.27
CHEMBL4102850 — — 2 6.12
CHEMBL4082962 — — 2 5.13
CHEMBL4100941 — — 2 -
CHEMBL4067631 — — 2 -
CHEMBL4088854 — — 2 -
CHEMBL4073558 — — 2 -
CHEMBL4100388 — — 2 -
CHEMBL4064965 — — 2 -
CHEMBL4092660 — — 2 -
CHEMBL4095090 — — 2 -
CHEMBL4061124 — — 2 -
CHEMBL4089295 — — 2 -
CHEMBL4078147 — — 2 -
CHEMBL4074402 — — 2 -
CHEMBL4093401 — — 2 -
CHEMBL4065785 — — 2 -
CHEMBL4077804 — — 2 -
CHEMBL4074635 — — 2 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL374478 RIFAMPIN IC50 = 40.0 nM 7.40
CHEMBL4095832 — IC50 = 190.0 nM 6.72
CHEMBL4084902 — IC50 = 320.0 nM 6.50
CHEMBL4103590 — IC50 = 360.0 nM 6.44
CHEMBL4065075 — IC50 = 540.0 nM 6.27
CHEMBL4102850 — IC50 = 760.0 nM 6.12
CHEMBL4082962 — IC50 = 7340.0 nM 5.13
CHEMBL4100388 — MIC90 > 100000.0 nM -
CHEMBL4100941 — MIC90 > 100000.0 nM -
CHEMBL4073558 — IC50 > 100000.0 nM -
CHEMBL4073558 — MIC90 > 100000.0 nM -
CHEMBL4088854 — IC50 > 100000.0 nM -
CHEMBL4088854 — MIC90 > 100000.0 nM -
CHEMBL4067631 — IC50 > 100000.0 nM -
CHEMBL4067631 — MIC90 > 100000.0 nM -
CHEMBL4100941 — IC50 > 100000.0 nM -
CHEMBL4074635 — MIC90 > 100000.0 nM -
CHEMBL4061124 — MIC90 > 100000.0 nM -
CHEMBL4064965 — MIC90 > 100000.0 nM -
CHEMBL4064965 — IC50 > 100000.0 nM -
CHEMBL4092660 — IC50 - — -
CHEMBL4092660 — MIC90 - — -
CHEMBL4102850 — MIC90 = 3760.0 nM -
CHEMBL4084902 — MIC90 = 5800.0 nM -
CHEMBL4095090 — IC50 - — -
CHEMBL4095090 — MIC90 - — -
CHEMBL4093401 — IC50 > 100000.0 nM -
CHEMBL4065785 — MIC90 > 100000.0 nM -
CHEMBL4061124 — IC50 > 100000.0 nM -
CHEMBL4089295 — MIC90 > 100000.0 nM -
CHEMBL4089295 — IC50 > 100000.0 nM -
CHEMBL4078147 — MIC90 > 100000.0 nM -
CHEMBL4078147 — IC50 > 100000.0 nM -
CHEMBL4074402 — MIC90 > 100000.0 nM -
CHEMBL4074402 — IC50 > 100000.0 nM -
CHEMBL4093401 — MIC90 > 100000.0 nM -
CHEMBL4082962 — MIC90 = 85930.0 nM -
CHEMBL4074635 — IC50 > 100000.0 nM -
CHEMBL4065785 — IC50 > 100000.0 nM -
CHEMBL4065075 — MIC90 = 7330.0 nM -
CHEMBL4103590 — MIC90 = 6260.0 nM -
CHEMBL4077804 — MIC90 > 100000.0 nM -
CHEMBL4077804 — IC50 > 100000.0 nM -
CHEMBL4095832 — MIC90 = 1760.0 nM -
CHEMBL374478 RIFAMPIN MIC90 = 980.0 nM -
CHEMBL4100388 — IC50 > 100000.0 nM -