Assay Detail
Binding
CHEMBL4026608
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Inhibition of TAMRA-labeled cRaf peptide binding to 14-3-3zeta (1 to 230 residues) (unknown origin) after 1 hr by fluorescence polarization assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein-Protein Interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.82 | 6.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4096939 | — | — | 1 | 6.08 |
| CHEMBL4069746 | — | — | 1 | 5.91 |
| CHEMBL4068123 | — | — | 1 | 5.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4096939 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4069746 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL4068123 | — | IC50 | = | 3290.0 | nM | 5.48 |