Assay Detail
Binding
CHEMBL4026847
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reactivation of cyclosarin inhibited human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated up to 60 mins followed by substrate addition measured for 3 mins by Ellman's method
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Application of the Ugi Multicomponent Reaction in the Synthesis of Reactivators of Nerve Agent Inhibited Acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 12 | 4.28 | 4.45 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4059560 | — | — | 1 | 4.45 |
| CHEMBL4079076 | — | — | 1 | 4.33 |
| CHEMBL4068829 | — | — | 1 | 4.05 |
| CHEMBL4069847 | — | — | 1 | - |
| CHEMBL4063984 | — | — | 1 | - |
| CHEMBL4091748 | — | — | 1 | - |
| CHEMBL4072579 | — | — | 1 | - |
| CHEMBL4099486 | — | — | 1 | - |
| CHEMBL4096126 | — | — | 1 | - |
| CHEMBL4081509 | — | — | 1 | - |
| CHEMBL748 | PRALIDOXIME CHLORIDE | 4.0 | 1 | - |
| CHEMBL291233 | OBIDOXIME CHLORIDE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4059560 | — | Kd | = | 35400.0 | nM | 4.45 |
| CHEMBL4079076 | — | Kd | = | 47200.0 | nM | 4.33 |
| CHEMBL4068829 | — | Kd | = | 89000.0 | nM | 4.05 |
| CHEMBL4069847 | — | Kd | = | 1144000.0 | nM | - |
| CHEMBL4063984 | — | Kd | = | 274000.0 | nM | - |
| CHEMBL4091748 | — | Kd | = | 228900.0 | nM | - |
| CHEMBL4072579 | — | Kd | = | 782000.0 | nM | - |
| CHEMBL4099486 | — | Kd | = | 1473000.0 | nM | - |
| CHEMBL4096126 | — | Kd | = | 167000.0 | nM | - |
| CHEMBL4081509 | — | Kd | = | 122000.0 | nM | - |
| CHEMBL748 | PRALIDOXIME CHLORIDE | Kd | = | 3159000.0 | nM | - |
| CHEMBL291233 | OBIDOXIME CHLORIDE | Kd | = | 945600.0 | nM | - |