Assay Detail
Binding
CHEMBL4026850
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reactivation of tabun inhibited human erythrocyte AChE using acetylthiocholine iodide as substrate preincubated up to 60 mins followed by substrate addition measured for 3 mins by Ellman's method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Application of the Ugi Multicomponent Reaction in the Synthesis of Reactivators of Nerve Agent Inhibited Acetylcholinesterase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 4.30 | 4.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4059560 | — | — | 1 | 4.77 |
| CHEMBL4068829 | — | — | 1 | 4.32 |
| CHEMBL4081509 | — | — | 1 | 4.10 |
| CHEMBL291233 | OBIDOXIME CHLORIDE | 2.0 | 1 | 4.01 |
| CHEMBL4096126 | — | — | 1 | - |
| CHEMBL748 | PRALIDOXIME CHLORIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4059560 | — | Kd | = | 17000.0 | nM | 4.77 |
| CHEMBL4068829 | — | Kd | = | 48000.0 | nM | 4.32 |
| CHEMBL4081509 | — | Kd | = | 80000.0 | nM | 4.10 |
| CHEMBL291233 | OBIDOXIME CHLORIDE | Kd | = | 97300.0 | nM | 4.01 |
| CHEMBL4096126 | — | Kd | = | 121000.0 | nM | - |
| CHEMBL748 | PRALIDOXIME CHLORIDE | Kd | = | 706000.0 | nM | - |