Assay Detail
Binding
CHEMBL4026982
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant full length His-tagged human IRAK4 expressed in baculovirus expression system using 5-FAM-IPTSPITTTYFFFKKK-COOH as substrate after 240 mins in presence of ATP by mobility shift assay
38
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Interleukin-1 receptor-associated kinase 4 (CHEMBL3778) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 7.34 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4102501 | — | — | 1 | 8.70 |
| CHEMBL4080574 | — | — | 1 | 8.70 |
| CHEMBL4078222 | — | — | 1 | 8.70 |
| CHEMBL4078625 | — | — | 1 | 8.52 |
| CHEMBL4067181 | — | — | 1 | 8.52 |
| CHEMBL4104802 | — | — | 1 | 8.52 |
| CHEMBL4087063 | — | — | 1 | 8.40 |
| CHEMBL4085735 | — | — | 1 | 8.30 |
| CHEMBL4064608 | — | — | 1 | 8.30 |
| CHEMBL4063689 | — | — | 1 | 8.30 |
| CHEMBL4089379 | — | — | 1 | 8.22 |
| CHEMBL4097418 | — | — | 1 | 8.22 |
| CHEMBL4081502 | — | — | 2 | 8.10 |
| CHEMBL4086115 | — | — | 1 | 8.05 |
| CHEMBL4091013 | — | — | 1 | 7.96 |
| CHEMBL4077215 | — | — | 1 | 7.89 |
| CHEMBL4061227 | — | — | 1 | 7.80 |
| CHEMBL4104915 | — | — | 1 | 7.66 |
| CHEMBL4067302 | — | — | 1 | 7.48 |
| CHEMBL4097089 | — | — | 1 | 7.36 |
| CHEMBL4079194 | — | — | 1 | 7.25 |
| CHEMBL4063127 | — | — | 1 | 7.00 |
| CHEMBL3361252 | — | — | 1 | 6.85 |
| CHEMBL4064168 | — | — | 1 | 6.85 |
| CHEMBL4088438 | — | — | 1 | 6.85 |
| CHEMBL4069890 | — | — | 1 | 6.72 |
| CHEMBL4075333 | — | — | 2 | 6.57 |
| CHEMBL4087705 | — | — | 1 | 6.39 |
| CHEMBL4094760 | — | — | 1 | 6.24 |
| CHEMBL4093475 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4102501 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4078222 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4080574 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4078625 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4067181 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4104802 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4087063 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4085735 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4064608 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4063689 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4097418 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4089379 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4081502 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4086115 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4091013 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4077215 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4061227 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4104915 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4067302 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4097089 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4079194 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4063127 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL4081502 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4064168 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3361252 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4088438 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4069890 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4075333 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL4075333 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4087705 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL4094760 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4093475 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL4069060 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4096351 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4079819 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4097847 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4105582 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4086053 | — | IC50 | > | 10000.0 | nM | - |