Assay Detail
Binding
CHEMBL4028190
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Inhibition of full length recombinant human N-terminal GST-tagged HDAC6 expressed in baculovirus infected insect cells using RHK-K(Ac)-AMC as substrate after 90 mins by fluorescence assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
(N-Hydroxycarbonylbenylamino)quinolines as Selective Histone Deacetylase 6 Inhibitors Suppress Growth of Multiple Myeloma in Vitro and in Vivo.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 7.89 | 9.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4104117 | — | — | 1 | 9.54 |
| CHEMBL4095667 | — | — | 1 | 9.10 |
| CHEMBL4063376 | — | — | 1 | 8.64 |
| CHEMBL4091237 | — | — | 1 | 8.63 |
| CHEMBL4098833 | — | — | 1 | 8.55 |
| CHEMBL4079874 | — | — | 1 | 8.49 |
| CHEMBL4085971 | — | — | 1 | 8.47 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 8.45 |
| CHEMBL4101436 | — | — | 1 | 8.45 |
| CHEMBL4073165 | — | — | 1 | 8.37 |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 8.33 |
| CHEMBL4068310 | — | — | 1 | 8.32 |
| CHEMBL4083449 | — | — | 1 | 8.23 |
| CHEMBL4093020 | — | — | 1 | 8.13 |
| CHEMBL4080790 | — | — | 1 | 8.02 |
| CHEMBL4064437 | — | — | 1 | 7.94 |
| CHEMBL4082487 | — | — | 1 | 7.71 |
| CHEMBL4083577 | — | — | 1 | 7.67 |
| CHEMBL4060607 | — | — | 1 | 7.60 |
| CHEMBL4069121 | — | — | 1 | 7.60 |
| CHEMBL4096377 | — | — | 1 | 7.38 |
| CHEMBL4065354 | — | — | 1 | 7.38 |
| CHEMBL4073021 | — | — | 1 | 6.89 |
| CHEMBL4088663 | — | — | 1 | 6.58 |
| CHEMBL4061807 | — | — | 1 | 6.39 |
| CHEMBL4060433 | — | — | 1 | 6.28 |
| CHEMBL4093718 | — | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4104117 | — | IC50 | = | 0.291 | nM | 9.54 |
| CHEMBL4095667 | — | IC50 | = | 0.795 | nM | 9.10 |
| CHEMBL4063376 | — | IC50 | = | 2.31 | nM | 8.64 |
| CHEMBL4091237 | — | IC50 | = | 2.33 | nM | 8.63 |
| CHEMBL4098833 | — | IC50 | = | 2.83 | nM | 8.55 |
| CHEMBL4079874 | — | IC50 | = | 3.25 | nM | 8.49 |
| CHEMBL4085971 | — | IC50 | = | 3.35 | nM | 8.47 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 3.55 | nM | 8.45 |
| CHEMBL4101436 | — | IC50 | = | 3.56 | nM | 8.45 |
| CHEMBL4073165 | — | IC50 | = | 4.24 | nM | 8.37 |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL4068310 | — | IC50 | = | 4.78 | nM | 8.32 |
| CHEMBL4083449 | — | IC50 | = | 5.89 | nM | 8.23 |
| CHEMBL4093020 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL4080790 | — | IC50 | = | 9.48 | nM | 8.02 |
| CHEMBL4064437 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL4082487 | — | IC50 | = | 19.6 | nM | 7.71 |
| CHEMBL4083577 | — | IC50 | = | 21.5 | nM | 7.67 |
| CHEMBL4060607 | — | IC50 | = | 25.3 | nM | 7.60 |
| CHEMBL4069121 | — | IC50 | = | 25.3 | nM | 7.60 |
| CHEMBL4096377 | — | IC50 | = | 41.7 | nM | 7.38 |
| CHEMBL4065354 | — | IC50 | = | 41.7 | nM | 7.38 |
| CHEMBL4073021 | — | IC50 | = | 129.0 | nM | 6.89 |
| CHEMBL4088663 | — | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL4061807 | — | IC50 | = | 403.0 | nM | 6.39 |
| CHEMBL4060433 | — | IC50 | = | 525.0 | nM | 6.28 |
| CHEMBL4093718 | — | IC50 | = | 1130.0 | nM | 5.95 |