Assay Detail
Binding
CHEMBL4028573
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ACMSD expressed in Pichia pastoris using ACMS as substrate by coupled spectrophotometric assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (CHEMBL4105941) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD+) Biosynthesis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.70 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4072240 | — | — | 1 | 8.52 |
| CHEMBL4071212 | — | — | 1 | 7.89 |
| CHEMBL4100715 | — | — | 1 | 7.70 |
| CHEMBL4067706 | — | — | 1 | 7.35 |
| CHEMBL4066693 | — | — | 1 | 7.05 |
| CHEMBL4097581 | — | — | 1 | 7.00 |
| CHEMBL4070405 | — | — | 1 | 6.82 |
| CHEMBL4088930 | — | — | 1 | 6.50 |
| CHEMBL4061780 | — | — | 1 | 5.98 |
| CHEMBL4082726 | — | — | 1 | 5.76 |
| CHEMBL4067044 | — | — | 1 | 5.72 |
| CHEMBL4093002 | — | — | 1 | 5.47 |
| CHEMBL1082811 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4072240 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4071212 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4100715 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4067706 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4066693 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4097581 | — | IC50 | = | 99.0 | nM | 7.00 |
| CHEMBL4070405 | — | IC50 | = | 151.0 | nM | 6.82 |
| CHEMBL4088930 | — | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL4061780 | — | IC50 | = | 1055.0 | nM | 5.98 |
| CHEMBL4082726 | — | IC50 | = | 1746.0 | nM | 5.76 |
| CHEMBL4067044 | — | IC50 | = | 1899.0 | nM | 5.72 |
| CHEMBL4093002 | — | IC50 | = | 3350.0 | nM | 5.47 |
| CHEMBL1082811 | — | IC50 | = | 4450.0 | nM | 5.35 |