Assay Detail
Binding
CHEMBL4029453
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Displacement of [33P]-S1P from human S1P3 receptor expressed in CHO cell membranes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Modulators of Sphingosine-1-phosphate Pathway Biology: Recent Advances of Sphingosine-1-phosphate Receptor 1 (S1P1) Agonists and Future Perspectives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.18 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL432067 | — | — | 1 | 9.15 |
| CHEMBL119256 | — | — | 1 | 8.57 |
| CHEMBL115713 | — | — | 1 | 7.75 |
| CHEMBL4077381 | — | — | 1 | 7.00 |
| CHEMBL4095976 | — | — | 1 | 6.55 |
| CHEMBL4072987 | — | — | 1 | 5.92 |
| CHEMBL4090982 | — | — | 1 | 5.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL432067 | — | IC50 | = | 0.71 | nM | 9.15 |
| CHEMBL119256 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL115713 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4077381 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4095976 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL4072987 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4090982 | — | IC50 | = | 4900.0 | nM | 5.31 |