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Assay Detail

CHEMBL4029475

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant human cytosolic carbonic anhydrase 1 pretreated for 15 mins prior to testing measured for 10 to 100 secs by phenol red based stopped-flow CO2 hydration assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Carbonic anhydrase 1 (CHEMBL261)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Evaluation of selenide, diselenide and selenoheterocycle derivatives as carbonic anhydrase I, II, IV, VII and IX inhibitors.
Angeli A, Tanini D, Viglianisi C, Panzella L, Capperucci A, Menichetti S, Supuran CT.
Bioorg Med Chem (2017) 25 : 2518 -2523
PubMed 28302505 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 24 4.49 6.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL20 ACETAZOLAMIDE 4.0 1 6.60
CHEMBL4101066 1 4.80
CHEMBL4083092 1 4.77
CHEMBL4095150 1 4.63
CHEMBL4086505 1 4.54
CHEMBL3314696 1 4.53
CHEMBL4104399 1 4.30
CHEMBL4072353 1 4.28
CHEMBL4082845 1 4.20
CHEMBL4067403 1 4.17
CHEMBL4060965 1 4.12
CHEMBL4085066 1 4.10
CHEMBL4063436 1 4.10
CHEMBL4069637 1 4.09
CHEMBL4088203 1 4.05
CHEMBL4059960 1 -
CHEMBL4073396 1 -
CHEMBL4090651 1 -
CHEMBL4076253 1 -
CHEMBL4063762 1 -
CHEMBL4099304 1 -
CHEMBL4101501 1 -
CHEMBL4077579 1 -
CHEMBL39469 BENZENE SELENOIC ACID 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL20 ACETAZOLAMIDE Ki = 250.0 nM 6.60
CHEMBL4101066 Ki = 15900.0 nM 4.80
CHEMBL4083092 Ki = 17100.0 nM 4.77
CHEMBL4095150 Ki = 23200.0 nM 4.63
CHEMBL4086505 Ki = 29100.0 nM 4.54
CHEMBL3314696 Ki = 29600.0 nM 4.53
CHEMBL4104399 Ki = 49500.0 nM 4.30
CHEMBL4072353 Ki = 52100.0 nM 4.28
CHEMBL4082845 Ki = 63600.0 nM 4.20
CHEMBL4067403 Ki = 67300.0 nM 4.17
CHEMBL4060965 Ki = 75900.0 nM 4.12
CHEMBL4085066 Ki = 79100.0 nM 4.10
CHEMBL4063436 Ki = 80100.0 nM 4.10
CHEMBL4069637 Ki = 81300.0 nM 4.09
CHEMBL4088203 Ki = 89800.0 nM 4.05
CHEMBL4059960 Ki > 100000.0 nM -
CHEMBL4073396 Ki > 100000.0 nM -
CHEMBL4090651 Ki > 100000.0 nM -
CHEMBL4076253 Ki > 100000.0 nM -
CHEMBL4063762 Ki > 100000.0 nM -
CHEMBL4099304 Ki > 100000.0 nM -
CHEMBL4101501 Ki > 100000.0 nM -
CHEMBL4077579 Ki > 100000.0 nM -
CHEMBL39469 BENZENE SELENOIC ACID Ki > 100000.0 nM -