Assay Detail
Functional
CHEMBL4029995
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Inhibition of LPS-induced NO production in mouse RAW264.7 cells preincubated for 1 hr followed by LPS stimulation measured after 24 hrs by Griess assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New derivatives of ursolic acid through the biotransformation by Bacillus megaterium CGMCC 1.1741 as inhibitors on nitric oxide production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.35 | 5.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4074068 | — | — | 1 | 5.91 |
| CHEMBL4094602 | — | — | 1 | 5.77 |
| CHEMBL50 | QUERCETIN | 3.0 | 1 | 5.36 |
| CHEMBL487887 | URSONIC ACID | — | 1 | 5.31 |
| CHEMBL4065446 | — | — | 1 | 4.40 |
| CHEMBL4086892 | — | — | 1 | - |
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4074068 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL4094602 | — | IC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL50 | QUERCETIN | IC50 | = | 4410.0 | nM | 5.36 |
| CHEMBL487887 | URSONIC ACID | IC50 | = | 4940.0 | nM | 5.31 |
| CHEMBL4065446 | — | IC50 | = | 40090.0 | nM | 4.40 |
| CHEMBL4086892 | — | IC50 | > | 60000.0 | nM | - |
| CHEMBL169 | URSOLIC ACID | IC50 | - | — | - |