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Assay Detail

CHEMBL4030074

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human MDA-MB-453 cells after 48 hrs by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MDA-MB-453
Confidence 1 — Organism
Curated By Autocuration

Target

MDA-MB-453 (CHEMBL614334)
Type CELL-LINE
Organism Homo sapiens

Publication

Design and synthesis of 1,2,3-triazolo-phenanthrene hybrids as cytotoxic agents.
Kumar NP, Nekkanti S, Sujana Kumari S, Sharma P, Shankaraiah N.
Bioorg Med Chem Lett (2017) 27 : 2369 -2376
PubMed 28431881 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 4.99 5.29

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4105661 1 5.29
CHEMBL4086656 1 5.19
CHEMBL4103078 1 4.90
CHEMBL4101317 1 4.87
CHEMBL4084162 1 4.72
CHEMBL4062195 1 -
CHEMBL4097916 1 -
CHEMBL4070809 1 -
CHEMBL4081404 1 -
CHEMBL4068090 1 -
CHEMBL4089278 1 -
CHEMBL4074619 1 -
CHEMBL4065218 1 -
CHEMBL4078804 1 -
CHEMBL4102134 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4105661 IC50 = 5100.0 nM 5.29
CHEMBL4086656 IC50 = 6500.0 nM 5.19
CHEMBL4103078 IC50 = 12600.0 nM 4.90
CHEMBL4101317 IC50 = 13500.0 nM 4.87
CHEMBL4084162 IC50 = 18900.0 nM 4.72
CHEMBL4062195 IC50 > 20000.0 nM -
CHEMBL4097916 IC50 > 20000.0 nM -
CHEMBL4070809 IC50 > 20000.0 nM -
CHEMBL4081404 IC50 > 20000.0 nM -
CHEMBL4068090 IC50 > 20000.0 nM -
CHEMBL4089278 IC50 > 20000.0 nM -
CHEMBL4074619 IC50 > 20000.0 nM -
CHEMBL4065218 IC50 > 20000.0 nM -
CHEMBL4078804 IC50 > 20000.0 nM -
CHEMBL4102134 IC50 > 20000.0 nM -